Mark C. Stahl, M.D.,Ph.D.
Fellowship, Movement DisordersUniversity of California - Los Angeles - Movement Disorders - 2014
Residency, NeurologyUniversity of California - Los Angeles, Neurology - 2012
Internship, Internal MedicineUniversity of California - San Diego - 2009
MD, PhD,Albert Einstein College of Medicine of Yeshiva University - 2008
- Assistant Professor of Neurology and Neural and Behavioral Sciences
- Deep Brain Stimulation (DBS)
My scientific interest is in the cell biology of neurodegenerative diseases, especially the role played by environmental influences on protein aggregation. I am investigating this through the use of tissue culture and small vertebrate animal (Zebrafish) models as well as patient samples. I am particularly interested in developing medium- and high- throughput screening of chemicals that trigger pathological processes related to neurodegeneration including abnormal protein folding, aggregation, and propagation as well as those that enhance potentially neuroprotective processes like autophagy, proteasome function, neuroinflammation, and mitochondrial motility and biogenesis. I am also interested in other types of environmental influences that may trigger neurodegeneration, such as traumatic brain injury, and how they may interface with a patient's genetics.
Techniques used in my laboratory include confocal and fluorescence microscopy, immunohistochemistry, western blot, RT-PCR, and FACS. In Zebrafish, we use CRISPR/Cas9 and morpholino-based genetic manipulation along with behavioral and structural analyses.
Overall, my research program aims to enhance our understanding of environmental contributions to neurodegenerative disease, and identify and develop novel ways of targeting the underlying pathogenesis.