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Epilepsy Center – Surgical Evaluation

Epilepsy Center – Surgical Evaluation

A graphic of an EEG with electrical activity of a normal brain.

Our team provides you with the most advanced resources for seizure detection and treatment.

Epilepsy surgery

In patients whose seizures are not controlled by medications (termed medically refractory), surgery provides the best chance of complete control of seizures. However, not all patients with refractory epilepsy are suitable candidates for surgery. In addition to being refractory, they need to have partial rather than generalized epilepsy (i.e., their epilepsy arises from a single part of the brain rather than from both sides or from all over the brain). Further, the epileptic region should be in a part of the brain that, if removed, is unlikely to result in major neurological complications. Whether or not patients are likely to benefit from surgery is determined by detailed testing (pre-surgical evaluation). As surgery offers the best hope for a cure in such patients, both adult and pediatric patients with intractable epilepsy are offered pre-surgical evaluation at Penn State Health Milton S. Hershey Medical Center. 

Pre-surgical evaluation consists of a two-phase process to determine if surgery is the best option and can provide good seizure control with minimal risk. Phase I involves all noninvasive (nonsurgical) tests. Phase II testing involves invasive tests (requires surgery) that are used in select patients.

Surgical Evaluation

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Penn State Neuroscience Institute
30 Hope Drive
Entrance B, Suite 1300
Hershey, Pa. 17033

Phase I Evaluation (noninvasive tests)

Not every patient requires every test available in the Phase I evaluation. Adult and pediatric epilepsy patients are evaluated by fellowship-trained epileptologists who determine the necessary and appropriate tests on an individualized basis. The following tests may be included in the phase I evaluation: 

Electroencephalography (EEG): This is the initial test performed in every patient and is usually done as an outpatient. It is used not only to diagnose epilepsy but also to determine if the epileptic seizures are coming from a small part of the brain (partial seizures) or all over the brain ( generalized). Although most patients do not have seizures when the EEG is being recorded, they often have abnormal brain activity in the EEG (spikes or sharp waves) that indicates they have a tendency to have seizures. The location of this activity allows the physician to determine whether patients have partial or generalized seizures.  

Inpatient video-EEG monitoring in adult and pediatric epilepsy monitoring units: This is the most important pre-surgical test and is performed with electrodes attached to the scalp (noninvasive monitoring). Patients are admitted to the hospital for several days and the purpose is to record seizures with simultaneous video and EEG. All the data are analyzed by a trained epileptologist. Detailed analysis of the symptoms during seizures as well as the location of EEG changes during seizures (ictal EEG onset), and abnormalities noted in between seizures (interictal), indicate the likely location where seizures originate within the brain.  

3-Tesla Magnetic Resonance Imaging (MRI): This may detect an abnormality that could be the cause of the epilepsy (lesional epilepsy) or may be normal (nonlesional epilepsy). With more powerful MRI machines and use of special protocols and software at our center, subtle brain abnormalities are increasingly being identified.

Positron emission tomography (PET): PET scans look at the metabolic activity of the brain and allow physicians to determine if the brain is functioning normally. In patients with epilepsy, decreased brain function is seen in the region where seizures originate, when the patient is not actually having a seizure. On the other hand, if the patient has a seizure during the test, increased brain function is seen.  PET scan may show abnormalities even if the brain MRI is normal. PET scans are usually done in the outpatient setting.  At our center, we record an EEG during the PET scan to avoid any confusion and confirm that the patient is not having a seizure.  

Single-photon emission computed tomography (SPECT): When a person has a seizure, an increased amount of blood flows to the brain region where the seizure begins.  SPECT scans performed during seizures can identify the brain region where blood flow increases and thus indicate where they begin.   SPECT scans are performed when the patient is admitted to the hospital for video-EEG monitoring.

Neuropsychological evaluation, functional MRI: Neuropsychological evaluation and functional MRI are used to assess cognitive functions, especially language and memory function prior to surgery, to see which side of the brain is dominant for language and to determine if there is decreased memory function in the epileptic region. This allows prediction of cognitive deficits after surgery. Functional MRI (fMRI) measures blood flow changes in areas of the brain during the performance of specific cognitive tasks. 

Intracarotid amobarbital/methohexital (Wada test): This test involves the injection of a medication such as sodium amobarbital or methohexital into one carotid artery at a time, and is performed in selected cases. The medication causes temporary (1-5 minutes) paralysis of one half of the brain allowing independent testing of language and memory function in the other half. This test is also used to predict post-operative deficits in language and memory function.

Results of video-EEG monitoring are compared with those obtained from the other tests to see if they all point to the same region of the brain as being the origin of epileptic seizures. If all the test results are concordant, the patient is likely to be a good surgical candidate.

Thus, the phase I evaluation is designed to find the area of the brain that is likely to be generating the seizures (the focus), to determine if that area can be safely removed, and predict what kind of outcome might be expected with regard to seizure reduction or seizure freedom.

After the phase I evaluation, the epilepsy team meets to discuss patient management options in a multi-disciplinary setting to individualize treatments.

At this conference, based on the results of the phase I evaluation, patients may be deemed good or poor surgical candidates. In some cases, it may be unclear and more testing is needed. This additional testing is called phase II evaluation and is performed in select cases, where despite all prior tests, the seizure focus is not defined well enough for surgical treatment. Phase II evaluation involves video-EEG monitoring with electrodes that are placed inside the skull (invasive monitoring). As there is a greater risk of complications from invasive monitoring, the decision about the necessity for a phase II evaluation is made by the epilepsy team as a whole and discussed in detail with the patient.

Phase II Evaluation

There are several surgical implantation options. Each involves the implantation of electrodes ― either on the surface of the brain or within the brain. The benefit of these electrodes is that they are closer to the area producing the seizures than those simply placed on the scalp. After surgical placement of electrodes, the patients are transferred to the epilepsy monitoring unit, and epileptologists perform video-EEG monitoring in a similar fashion to the phase I monitoring.

The electrode types and implantation arrays differ and may include:

Subdural electrodes: A subdural electrode grid is a thin sheet of material with multiple small (several millimeters in size) recording electrodes implanted within it. These are placed directly on the surface of the brain and have the advantage of recording the EEG without the interference of skin, fat tissue, muscle and bone that may limit scalp EEG. Shapes and sizes of these sheets are chosen to best conform to the surface of the brain and the area of interest.  

Depth electrodes: These are small wires which are implanted within the brain itself. Each wire has electrodes which surround it. These electrodes are able to record brain activity along the entire length of the implanted wire. They have the advantage of recording activity from structures deeper in the brain. 

Combination: In a number of instances, it is beneficial to implant a combination of subdural electrodes and depth electrodes.  

Stereoelectroencephalography: In rare instances, it may be best to approach invasive monitoring with a stereoelectroencephalography approach (stereoEEG). With this approach, multiple depth electrodes are implanted in a specific pattern that is individualized to the patient. The three-dimensional space covered by the depth electrodes is designed to encompass the seizure focus.

Functional mapping: Functional mapping is usually performed in patients with implanted subdural electrodes while they are in the Epilepsy Monitoring Unit. After a sufficient number of seizures are recorded, brief electrical stimulation is provided through each electrode separately to determine the normal function of the part of the brain underneath the electrode. This procedure is painless. The purpose is to map out critically important areas of the brain, such as those necessary for motor, sensory and language functions, and determine if there is any overlap with the seizure-generating regions. This allows tailoring of surgical resections to minimize the risk of major neurological deficits after surgery.

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